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Zofran is the trade name for ondansetron. Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. Medically reviewed by Drugs.com. Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Oculogyric crisis occurred alone and in combination with other dystonic reactions. Abnormal Heart Electrical Signals 2. We comply with the HONcode standard for trustworthy health information -. difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating, The most frequently reported side effects are headache, constipation, and diarrhea. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. Available for Android and iOS devices. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. Applies to ondansetron: film, solution, tablet, tablet disintegratingOther dosage forms: 1. injection solutionAlong with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. It can also cause other side effects. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. The National Institutes of Health lists the following as common side effects. Side Effects. It is ineffective for treating vomiting caused by motion sickness. Prolonged QT Interval On EKG 12. If these effects persist or worsen, notify your doctor promptly. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment. Shock 13. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. "Product Information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Zofran is available in generic form. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Some side effects may not be reported. What Are Side Effects of Zofran? [Ref], Very common (10% or more): Headache (up to 27%), drowsiness/sedation (up to 23%), Common (1% to 10%): Dizziness, paresthesia, Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia), Rare (0.01% to 0.1%): Grand mal seizures[Ref]. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. "Product Information. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. [Ref], Very common (10% or more): Eye disorder (up to 19%), Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision), Very rare (less than 0.01%): Transient blindness, Frequency not reported: Swollen periocular area[Ref], Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation. All medications have side effects, including Zofran. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking onda How long before a meal should you take ondansetron? Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. All rights reserved. Zofran May Cause Harmful Interactions With Certain Foods, Drugs, And Medical Conditions There's a lot of controversy surrounding the anti-nausea medication Zofran, particularly when it's used by pregnant women. Call your doctor at once if you have: You may report them to the FDA. 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